منابع مشابه
The connexion between active cation transport and metabolism in erythrocytes.
1. A study has been made of the dependence on the concentrations of internal Na(+) and external K(+) of lactate and phosphate production in human erythrocytes. 2. Lactate production was stimulated by Na(+) and K(+) but only when they were internal and external respectively. The stimulation was counteracted by ouabain. The production of phosphate was affected in the same way. 3. There is a quant...
متن کاملOuabain binding and cation transport in human erythrocytes.
In the present studies we have explored the relation between ouabain binding and the inhibition of potassium influx in intact human erythrocytes. The rate at which bound ouabain molecules dissociate from the erythrocyte membrane is not altered by complete replacement of choline with sodium or by partial replacement with potassium. These findings indicate that the effects of these cations on oua...
متن کاملCation Exchange in Mammalian Erythrocytes
Freshly drawn heparinized human whole blood is exposed to x-rays in amounts up to 54,000 r in vitro and then equilibrated under a controlled atmosphere at 24 or 38 degrees C. For as long as 26 hours following exposure, potassium is progressively lost from the cells and quantitatively replaced by sodium with little, if any, osmotic disturbance. The mean rate of loss at 20,000 r and 24 degrees C....
متن کاملEnergy metabolism in human erythrocytes: the role of phosphoglycerate kinase in cation transport.
Three models of disturbed erythrocyte metabolism, triose-depleted normal, phosphoglycerate kinase (PGK)-deficient, and pyruvate kinase (PK)-deficient cells, have been studied to examine further the role of PGK in erythrocyte cation transport. Sodium (Na-+) and potassium (K-+) transport were reduced only in cells fully depleted of triose. In such cells the PGK step presumably was inoperative due...
متن کاملStrain-specific variations in cation content and transport in mouse erythrocytes.
Studies of ion transport pathophysiology in hematological disorders and tests of possible new therapeutic agents for these disorders have been carried out in various mouse models because of close functional similarities between mouse and human red cells. We have explored strain-specific differences in erythrocyte membrane physiology in 10 inbred mouse strains by determining erythrocyte contents...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1954
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1954.sp005156